Assessing the validity of eyelid parameters to detect impairment due to benzodiazepines
Vanessa E Wilkinson, Melinda L Jackson, Justine Westlake, Bronwyn Stevens, Maree Barnes, Jennifer Cori, Philip Swann, Mark E Howard
HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL | WILEY | Published : 2020
OBJECTIVE: Benzodiazepines impair driving ability and psychomotor function. Eyelid parameters accurately reflect drowsiness; however, the effects of benzodiazepines on these measures have not been extensively studied. The aim of this study was to investigate the effect of benzodiazepines on eyelid parameters and evaluate their accuracy for detecting psychomotor impairment. METHODS: Eyelid parameters were recorded during a psychomotor vigilance task (PVT) and driving simulation over 2 days, baseline, and after 20-mg oral temazepam. The utility of eyelid parameters for detecting PVT lapses was evaluated using receiver operating characteristic curves, and cut-off levels indicating impairment (≥..View full abstract
Dr Howard has received funding from the CRC for Alertness, Safety and Productivity, ResMed Foundation, Edansafe, and Prevention Express; received nonfinancial support from Sleep Diagnostics; and is a consultant for the National Transport Commission and VicRoads.