Journal article

Effect of Vancomycin or Daptomycin With vs Without an Antistaphylococcal beta-Lactam on Mortality, Bacteremia, Relapse, or Treatment Failure in Patients With MRSA Bacteremia A Randomized Clinical Trial

Steven YC Tong, David C Lye, Dafna Yahav, Archana Sud, J Owen Robinson, Jane Nelson, Sophia Archuleta, Matthew A Roberts, Alan Cass, David L Paterson, Hong Foo, Mical Paul, Stephen D Guy, Adrian R Tramontana, Genevieve B Walls, Stephen McBride, Narin Bak, Niladri Ghosh, Benjamin A Rogers, Anna P Ralph Show all

JAMA | AMER MEDICAL ASSOC | Published : 2020

Abstract

Importance: Methicillin-resistant Staphylococcus aureus (MRSA) bacteremia is associated with mortality of more than 20%. Combining standard therapy with a β-lactam antibiotic has been associated with reduced mortality, although adequately powered randomized clinical trials of this intervention have not been conducted. Objective: To determine whether combining an antistaphylococcal β-lactam with standard therapy is more effective than standard therapy alone in patients with MRSA bacteremia. Design, Setting, and Participants: Open-label, randomized clinical trial conducted at 27 hospital sites in 4 countries from August 2015 to July 2018 among 352 hospitalized adults with MRSA bacteremia. Foll..

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Grants

Awarded by Australian National Health and Medical Research Council


Awarded by Singapore National Medical Research Council


Awarded by Ramiciotti Foundation


Funding Acknowledgements

The study was funded by competitive grants from the Australian National Health and Medical Research Council (grant 1078930) and the Singapore National Medical Research Council (grant 0001-001094) and by seed funding from the Ramiciotti Foundation (grant ES2014/079). Drs Tong, Ralph, and Davis are Australian National Health and Medical Research Council Career development fellows (grants 1145033, 1142011, and 1160331, respectively). Dr Davies is an Australian National Health and Medical Research Council early career fellow (1123427).