Journal article

Methylcellulose Hydrogel with Melissa officinalis Essential Oil as a Potential Treatment for Oral Candidiasis

Elisa Serra, Fabien Saubade, Cosimo Ligorio, Kathryn Whitehead, Alastair Sloan, David W Williams, Araida Hidalgo-Bastida, Joanna Verran, Sladjana Malic

MICROORGANISMS | MDPI | Published : 2020

Abstract

Candida spp. are the most prevalent fungi of the human microbiota and are opportunistic pathogens that can cause oral candidiasis. Management of such infections is limited due to the low number of antifungal drugs available, their relatively high toxicity and the emergence of antifungal resistance. Therefore, much interest in the antimicrobial potential of natural compounds has recently been evident. The use of hydrogels in the delivery of biocides has been explored due to their biocompatibility, ease with drug encapsulation, and due to their potential to confer mechanical and structural properties similar to biological tissue. Methylcellulose hydrogels (10% (w/v)) with 1% (v/v) and 2% (v/v)..

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University of Melbourne Researchers

Grants

Awarded by EPSRC


Awarded by MRC CDT in Regenerative Medicine


Funding Acknowledgements

This research was funded by Manchester Metropolitan University. C.L. thanks the EPSRC & MRC CDT in Regenerative Medicine for their financial support (EP/L014904/1).