Interrogating the Osteogenic Potential of Implant Surfaces In Vitro: A Review of Current Assays
Steven James Avery, Wayne Nishio Ayre, Alastair James Sloan, Rachel Jane Waddington
TISSUE ENGINEERING PART B-REVIEWS | MARY ANN LIEBERT, INC | Published : 2020
The success of implantable devices relies heavily on their interaction with the host cells facilitating the osseointegration process. However, with so many new surface modifications, with subtly varying design parameters, in vitro assays can, with proper interpretation, provide valuable information for understanding cellular behavior. This review brings together pertinent in vitro experimental protocols available to researchers and discusses them in relationship to the development of the osteoblast phenotype during bone repair. Consideration is also paid to the influence of endothelial and macrophage cells that can substantially change osteogenic cell activity and thus can provide added valu..View full abstract
Awarded by Innovate UK Knowledge transfer partnerships
The authors are grateful for funding via Innovate UK Knowledge transfer partnerships, (grant no 101454) and Renishaw plc.