Journal article

A novel dual action monolithic thermosetting hydrogel loaded with lidocaine and metronidazole as a potential treatment for alveolar osteitis

Lena Bender, Hannah M Boostrom, Carmine Varricchio, Marika Zuanon, Vildan Celiksoy, Alastair Sloan, Jonathan Cowpe, Charles M Heard

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS | ELSEVIER | Published : 2020

Abstract

Alveolar osteitis is a complication that can occur after tooth extraction, whereby exposed bone results in severe throbbing pain for the patient and can be prone to infection. The current treatment options are widely regarded as sub-optimal. The aim of this project was to investigate in vitro the plausibility of a dual-action monolithic drug-loaded thermosensitive hydrogel that undergoes thermal gelation within the tooth socket and releases both anaesthetic and antimicrobial agents. Hydrogels containing different levels of lidocaine HCl and metronidazole were prepared based upon Carbopol 934P NF and Pluronic F-127 blends. Membrane-less drug release was determined from the set hydrogels into ..

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University of Melbourne Researchers