Journal article

Can octapeptin antibiotics combat extensively drug-resistant (XDR) bacteria?

Mark AT Blaskovich, Miranda E Pitt, Alysha G Elliott, Matthew A Cooper

Expert Review of Anti-infective Therapy | TAYLOR & FRANCIS LTD | Published : 2018

Abstract

INTRODUCTION: The octapeptins are a family of cyclic lipopeptides first reported in the 1970s then largely ignored. At the time, their reported antibiotic activity against polymyxin-resistant bacteria was a curiosity. Today, the advent of widespread drug resistance in Gram-negative bacteria has prompted their 'rediscovery.' The paucity of new antibiotics in the clinical pipeline is coupled with a global spread of increasing antibiotic resistance, particularly to meropenem and polymyxins B and E (colistin). Areas covered: We review the original discovery of octapeptins, their recent first chemical syntheses, and their mode of action, then discuss their potential as a new class of antibiotics ..

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University of Melbourne Researchers

Grants

Awarded by Department of Health, Australian Government, National Health and Medical Research Council


Awarded by U.S. Department of Health and Human Services, National Institutes of Health, National Institute of Allergy and Infectious Diseases


Awarded by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES


Funding Acknowledgements

The manuscript was funded by the Department of Health, Australian Government, National Health and Medical Research Council through the following grants; APP1005350, APP1045326, APP1059354, APP1139609 and U.S. Department of Health and Human Services, National Institutes of Health, National Institute of Allergy and Infectious Diseases through the following grants; R21A1098731/R33A1098731-03.