Brushed polyethylene glycol and phosphorylcholine for grafting nanoparticles against protein binding
Bo Wang, Thomas Blin, Aleksandr Kakinen, Xinwei Ge, Emily H Pilkington, John F Quinn, Michael R Whittaker, Thomas P Davis, Pu Chun Ke, Feng Ding
Polymer Chemistry | ROYAL SOC CHEMISTRY | Published : 2016
To provide a molecular insight for guiding polymer coating in surface science and nanotechnology, here we examined the structures of brushed polyethylene glycol(bPEG)- and phosphorylcholine(bPC)-grafted iron oxide nanoparticles and analyzed their protein avoiding properties. We show bPC as an advantageous biomimetic alternative to PEG in rendering stealth nanostructures.
Awarded by ARC Project
Awarded by NSF CAREER
Awarded by NIH
Awarded by NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
Awarded by Directorate For Engineering
Awarded by Div Of Chem, Bioeng, Env, & Transp Sys
This work was supported by ARC Project CE140100036 (Davis), NSF CAREER CBET-1553945 (Ding), and NIH R15ES022766-01A1 (Ding). Davis is thankful for the award of an Australian Laureate Fellowship from the ARC.