Journal article

Brushed polyethylene glycol and phosphorylcholine for grafting nanoparticles against protein binding

Bo Wang, Thomas Blin, Aleksandr Kakinen, Xinwei Ge, Emily H Pilkington, John F Quinn, Michael R Whittaker, Thomas P Davis, Pu Chun Ke, Feng Ding

Polymer Chemistry | ROYAL SOC CHEMISTRY | Published : 2016

Abstract

To provide a molecular insight for guiding polymer coating in surface science and nanotechnology, here we examined the structures of brushed polyethylene glycol(bPEG)- and phosphorylcholine(bPC)-grafted iron oxide nanoparticles and analyzed their protein avoiding properties. We show bPC as an advantageous biomimetic alternative to PEG in rendering stealth nanostructures.

Grants

Awarded by ARC Project


Awarded by NSF CAREER


Awarded by NIH


Awarded by NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES


Awarded by Directorate For Engineering


Awarded by Div Of Chem, Bioeng, Env, & Transp Sys


Funding Acknowledgements

This work was supported by ARC Project CE140100036 (Davis), NSF CAREER CBET-1553945 (Ding), and NIH R15ES022766-01A1 (Ding). Davis is thankful for the award of an Australian Laureate Fellowship from the ARC.