Journal article

Cofibrillization of Pathogenic and Functional Amyloid Proteins with Gold Nanoparticles against Amyloidogenesis

Ibrahim Javed, Yunxiang Sun, Jozef Adamcik, Bo Wang, Aleksandr Kakinen, Emily H Pilkington, Feng Ding, Raffaele Mezzenga, Thomas P Davis, Pu Chun Ke

Biomacromolecules | AMER CHEMICAL SOC | Published : 2017

Abstract

Biomimetic nanocomposites and scaffolds hold the key to a wide range of biomedical applications. Here we show, for the first time, a facile scheme of cofibrillizing pathogenic and functional amyloid fibrils via gold nanoparticles (AuNPs) and their applications against amyloidogenesis. This scheme was realized by β-sheet stacking between human islet amyloid polypeptide (IAPP) and the β-lactoglobulin "corona" of the AuNPs, as revealed by transmission electron microscopy, 3D atomic force microscopy, circular dichroism spectroscopy, and molecular dynamics simulations. The biomimetic AuNPs eliminated IAPP toxicity, enabled X-ray destruction of IAPP amyloids, and allowed dark-field imaging of path..

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