Journal article

The Importance of Poly(ethylene glycol) Alternatives for Overcoming PEG Immunogenicity in Drug Delivery and Bioconjugation

Thanh Hoang Thi Thai, Emily H Pilkington, Hai Nguyen Dai, Jung Seok Lee, Ki Dong Park, Nghia P Truong

Polymers | MDPI | Published : 2020

Abstract

Poly(ethylene glycol) (PEG) is widely used as a gold standard in bioconjugation and nanomedicine to prolong blood circulation time and improve drug efficacy. The conjugation of PEG to proteins, peptides, oligonucleotides (DNA, small interfering RNA (siRNA), microRNA (miRNA)) and nanoparticles is a well-established technique known as PEGylation, with PEGylated products have been using in clinics for the last few decades. However, it is increasingly recognized that treating patients with PEGylated drugs can lead to the formation of antibodies that specifically recognize and bind to PEG (i.e., anti-PEG antibodies). Anti-PEG antibodies are also found in patients who have never been treated with ..

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Grants

Awarded by DECRA Fellowship from the Australian Research Council


Awarded by Australian Research Council


Funding Acknowledgements

N.P.T. acknowledges the award of a DECRA Fellowship (DE180100076) and a Discovery Project grant (DP200100231) from the Australian Research Council.