Crim1-, a regulator of developmental organogenesis
Swati Iyer, David J Pennisi, Michael Piper
Histology and Histopathology | F HERNANDEZ | Published : 2016
The regulation of growth factor localization, availability and activity is critical during embryogenesis to ensure appropriate organogenesis. This process is regulated through the coordinated expression of growth factors and their cognate receptors, as well as via proteins that can bind, sequester or localize growth factors to distinct locations. One such protein is the transmembrane protein Crim1. This protein has been shown to be expressed broadly within the developing embryo, and to regulate organogenesis within the eye, kidney and placenta. Mechanistically, Crim1 has been revealed to mediate organogenesis via its interaction with growth factors including TGFβs, BMPs, VEGFs and PDFGs. Mor..View full abstract
Awarded by National Health and Medical Research Council
Awarded by Australian Research Council Future Fellowship
This work was funded by grants from the National Health and Medical Research Council to MP (1057751) and DJP (631658). MP holds an Australian Research Council Future Fellowship (FT120100170). SI was supported by a UQ Research Scholarship. We gratefully acknowledge Dr. Diane Maresco-Pennisi for reading preliminary drafts of the review.