Journal article
Usp9x-deficiency disrupts the morphological development of the postnatal hippocampal dentate gyrus
Sabrina Oishi, Susitha Premarathne, Tracey J Harvey, Swati Iyer, Chantelle Dixon, Suzanne Alexander, Thomas HJ Burne, Stephen A Wood, Michael Piper
Scientific Reports | NATURE PUBLISHING GROUP | Published : 2016
DOI: 10.1038/srep25783
Abstract
Within the adult mammalian brain, neurogenesis persists within two main discrete locations, the subventricular zone lining the lateral ventricles, and the hippocampal dentate gyrus. Neurogenesis within the adult dentate gyrus contributes to learning and memory, and deficiencies in neurogenesis have been linked to cognitive decline. Neural stem cells within the adult dentate gyrus reside within the subgranular zone (SGZ), and proteins intrinsic to stem cells, and factors within the niche microenvironment, are critical determinants for development and maintenance of this structure. Our understanding of the repertoire of these factors, however, remains limited. The deubiquitylating enzyme USP9X..
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Awarded by National Health and Medical Research Council
Awarded by Australian Research Council
Funding Acknowledgements
We thank Lachlan Harris, Luke Hammond and Daniel Matthews for technical assistance. This work was supported by National Health and Medical Research Council project grants (grant numbers 1003462, 1057751 and 1022308 to MP). MP was supported by a fellowship (Australian Research Council Future Fellowship; FT120100170). SI was supported by a UQ Research Scholarship. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.