Journal article

Cell Surfactomes of Two Endometrial Epithelial Cell Lines That Differ in Their Adhesiveness to Embryonic Cells

Sonali R Bhagwat, Tejashree Redij, Kruttika Phalnikar, Sumeet Nayak, Swati Iyer, Sushama Gadkar, Uddhav Chaudhari, Sanjeeva D Kholkute, Geetanjali Sachdeva

Molecular Reproduction and Development | WILEY | Published : 2014

Abstract

Adhesiveness of the endometrial epithelium to an embryo plays a critical role in the initiation of pregnancy. Loss or gain of adhesiveness also dictates the potential of endometrial epithelial cells to metastasize, an event that can result from certain genetic insults. A proteomics-based exploration of the "adhesiveness" these epithelial cells was employed that could identify targets that could disrupt embryo-endometrium interactions and/or metastasis of endometrial cancer cells. The present study defined the surfactomes of two human endometrial epithelial cell lines known for their differential adhesiveness to embryonic cells. Comparative, two-dimensional electrophoretic analysis of the sur..

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University of Melbourne Researchers