Zinc Transporter-3 Knockout Mice Demonstrate Age-Dependent Alterations in the Metalloproteome
Sara M Hancock, Stuart D Portbury, Adam P Gunn, Blaine R Roberts, Ashley I Bush, Paul A Adlard
International Journal of Molecular Sciences | MDPI | Published : 2020
Metals are critical cellular elements that are involved in a variety of cellular processes, with recent literature demonstrating that zinc, and the synaptic zinc transporter (ZnT3), are specifically involved in learning and memory and may also be key players in age-related neurodegenerative disorders such as Alzheimer's disease. Whilst the cellular content and location of metals is critical, recent data has demonstrated that the metalation state of proteins is a determinant of protein function and potential toxicity. As we have previously reported that ZnT3 knockout (KO) mice have deficits in total zinc levels at both 3 and 6 months of age, we were interested in whether there might be change..View full abstract
The Florey Institute of Neuroscience and Mental Health acknowledge the strong support from the Victorian Government and in particular the funding from the Operational Infrastructure Support Grant.