Injectable and Sprayable Polyphenol-Based Hydrogels for Controlling Hemostasis
H Geng, Q Dai, H Sun, L Zhuang, A Song, F Caruso, J Hao, J Cui
ACS Applied Bio Materials | American Chemical Society | Published : 2020
Injectable and sprayable hydrogels have attracted considerable attention for application in the biomedical field owing to their high moldability and efficiency in encapsulating therapeutics and cells. Herein, we report the spontaneous assembly of injectable and sprayable hydrogels via a one-step mixing of solutions of tannic acid (TA) and O-carboxymethyl chitosan (CMCS) without an external stimulus. The presence of 1,4-benzenediboronic acid (BDBA) improves the mechanical properties and reduces the gelation time of the resulting hydrogels. The hydrogels assemble via hydrogen bonds between TA and CMCS as well as via dynamic boronate ester bonds between TA and BDBA, as confirmed by Fourier tran..View full abstract
This research was funded by the National Natural Science Foundation of China (J.C., 21872085; Q.D., 21802088) and the Natural Science Foundation of Shandong Province (H.G., ZR2019BB056; Q.D., ZR2018BB036).