Journal article

Microstructural correlates of 23Na relaxation in human brain at 7 Tesla.

Scott C Kolbe, Warda Syeda, Yasmin Blunck, Rebecca Glarin, Meng Law, Leigh A Johnston, Jon O Cleary

Neuroimage | Elsevier | Published : 2020

Abstract

23Na provides the second strongest MR-observable signal in biological tissue and exhibits bi-exponential T2∗ relaxation in micro-environments such as the brain. There is significant interest in developing 23Na biomarkers for neurological diseases that are associated with sodium channel dysfunction such as multiple sclerosis and epilepsy. We have previously reported methods for acquisition of multi-echo sodium MRI and continuous distribution modelling of sodium relaxation properties as surrogate markers of brain microstructure. This study aimed to compare 23Na T2∗ relaxation times to more established measures of tissue microstructure derived from advanced diffusion MRI at 7 T. Six healthy vol..

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Grants

Funding Acknowledgements

This work was supported by Melbourne Neuroscience Institute, University of Melbourne. We acknowledge the facilities, and the scientific and technical assistance of the Australian National Imaging Facility at the Melbourne Brain Centre Imaging Unit. The Australian National Imaging Facility is funded by the Australian Government NCRIS program. The work was also supported by a research collaboration agreement with Siemens Healthcare. The MP2RAGE data was acquired with a “Works in Progress” prototype sequence provided by Siemens Healthineers. JOC was supported by a University of Melbourne McKenzie Fellowship.