Inactivation of Zeb1 in GRHL2-deficient mouse embryos rescues mid-gestation viability and secondary palate closure
Marina R Carpinelli, Michael E de Vries, Alana Auden, Tariq Butt, Zihao Deng, Darren D Partridge, Lee B Miles, Smitha R Georgy, Jody J Haigh, Charbel Darido, Simone Brabletz, Thomas Brabletz, Marc P Stemmler, Sebastian Dworkin, Stephen M Jane
DISEASE MODELS & MECHANISMS | COMPANY BIOLOGISTS LTD | Published : 2020
Cleft lip and palate are common birth defects resulting from failure of the facial processes to fuse during development. The mammalian grainyhead-like (Grhl1-3) genes play key roles in a number of tissue fusion processes including neurulation, epidermal wound healing and eyelid fusion. One family member, Grhl2, is expressed in the epithelial lining of the first pharyngeal arch in mice at embryonic day (E)10.5, prompting analysis of the role of this factor in palatogenesis. Grhl2-null mice die at E11.5 with neural tube defects and a cleft face phenotype, precluding analysis of palatal fusion at a later stage of development. However, in the first pharyngeal arch of Grhl2-null embryos, dysregul..View full abstract
Awarded by Australian National Health and Medical Research Council
Awarded by Australian Research Council
This work was supported by the Australian National Health and Medical Research Council (project grant 1063837) and the Australian Research Council (Discovery Early Career Researcher Award 140100500 to S.D.).