Improved irritability, mood, and quality of life following introduction of perampanel as late adjunctive treatment for epilepsy

JS Moraes; G Hepworth; S Ignatiadis; A Dharan; R Carne; U Seneviratne; MJ Cook; WJ D'Souza

Journal article

Improved irritability, mood, and quality of life following introduction of perampanel as late adjunctive treatment for epilepsy

JS Moraes, G Hepworth, S Ignatiadis, A Dharan, R Carne, U Seneviratne, MJ Cook, WJ D'Souza

Epilepsy and Behavior | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2020

DOI: 10.1016/j.yebeh.2019.106883

Abstract

Objective: The objective of this study was to evaluate the efficacy and tolerability of perampanel (PER) in late adjunctive treatment of focal epilepsy. We assessed outcomes 1) according to patients' clinical profiles and the broad mechanism of action (MoA) of concomitant antiepileptic drugs (AEDs) and 2) the effects of PER on adverse events, irritability, mood, and quality of life (QOL). Methods: Consecutive patients commenced on PER at two epilepsy centers in Melbourne, Australia were identified. A nested cohort underwent detailed prospective assessment, while the remainder were retrospectively analyzed. Six- and 12-month efficacy endpoints were at least a 50% reduction in seizure frequenc..

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University of Melbourne Researchers

Graham Hepworth Author

Sophia Ignatiadis Author

Udaya Seneviratne Author

Mark Cook Author

Grants

Funding Acknowledgements

This study was supported by an investigator-initiated grant from EISAI Australia Pty Limited. Eisai was not involved in the study design, the collection, analysis, and interpretation of the data gathered, the writing of the report, or the decision to submit the article for publication.