A Neural basis for Octanoic acid regulation of energy balance
Vanessa R Haynes, Natalie J Michael, Marco van den Top, Fei-Yue Zhao, Russell D Brown, David De Souza, Garron T Dodd, David Spanswick, Matthew J Watt
MOLECULAR METABOLISM | ELSEVIER | Published : 2020
OBJECTIVES: Nutrient sensing by hypothalamic neurons is critical for the regulation of food intake and energy expenditure. We aimed to identify long- and medium-chain fatty acid species transported into the brain, their effects on energy balance, and the mechanisms by which they regulate activity of hypothalamic neurons. METHODS: Simultaneous blood and cerebrospinal fluid (CSF) sampling was undertaken in rats and metabolic analyses using radiolabeled fatty acid tracers were performed on mice. Electrophysiological recording techniques were used to investigate signaling mechanisms underlying fatty acid-induced changes in activity of pro-opiomelanocortin (POMC) neurons. RESULTS: Medium-chain fa..View full abstract
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Awarded by National Health and Medical Research Council of Australia (NHMRC)
Awarded by NHMRC
This study was supported by the National Health and Medical Research Council of Australia (NHMRC, ID: 1079233, 1084600, and 1063955), the Diabetes Australia Research Trust, and NeuroSolutions Ltd, UK. MJW is supported by a Senior Research Fellowship from the NHMRC (ID: 1077703). This work was supported by infrastructure and technical assistance from the Melbourne Mouse Metabolic Phenotyping Platform (MMMPP) at the University of Melbourne.