Journal article

Th17 cell plays a role in the pathogenesis of Hashimoto's thyroiditis in patients.

Dapeng Li, Wenqian Cai, Runxia Gu, Yi Zhang, Huafeng Zhang, Ke Tang, Pingwei Xu, Foad Katirai, Wei Shi, Longqiang Wang, Tao Huang, Bo Huang

Clinical Immunology | Published : 2013

Abstract

Hashimoto's thyroiditis (HT) has long been epidemiologically associated with excess iodine levels. However, the underlying immunological mechanisms still remain largely unexplored. Th17 cells are commonly recognized as playing vital roles in various autoimmune diseases. Here we show that intra-thyroid infiltrating Th17 cells and serum IL-17 levels were significantly increased in HT patients. However, the concentration of serum IL-17 was inversely correlated with patients' residual thyroid function while the heterogeneously expressed thyroid IL-17 was directly correlated with local fibrosis. Administration of moderate high levels of iodine was found to facilitate the polarization of murine sp..

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University of Melbourne Researchers