Journal article

Early Life Parechovirus Infection Neurodevelopmental Outcomes at 3 Years: A Cohort Study

Philip N Britton, Karen Walker, Brendan McMullan, Claire Galea, Rebecca Burrell, Bronte Morgan, Ingrid Honan, Suzy Teutsch, Hayley Smithers-Sheedy, Natalie Fairbairn, Richard Mattick, Delyse Hutchinson, Cheryl A Jones

The Journal of Pediatrics | MOSBY-ELSEVIER | Published : 2020

Abstract

OBJECTIVE: To investigate the long-term developmental and behavioral outcomes in an established cohort of children hospitalized as infants with human parechovirus (HPeV) infection and sepsis-like illness. STUDY DESIGN: The HPeV cohort was composed of children 3 years of age after HPeV infection and hospitalization in early infancy that occurred during a well-documented HPeV genotype 3 outbreak in Australia. We assessed neurodevelopmental and behavioral outcomes using the Bayley Scales of Infant and Toddler Development-III and the Child Behavior Checklist. We compared their outcomes with a subsample of healthy control infants drawn from the independently sampled Triple B Pregnancy Cohort Stud..

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