Genetic Modulators of Traumatic Brain Injury in Animal Models and the Impact of Sex-Dependent Effects
Chaitanya Inampudi, Giuseppe D Ciccotosto, Roberto Cappai, Peter J Crack
Journal of Neurotrauma | MARY ANN LIEBERT, INC | Published : 2020
Traumatic brain injury (TBI) is a major health problem causing disability and death worldwide. There is no effective treatment, due in part to the complexity of the injury pathology and factors affecting its outcome. The extent of brain injury depends on the type of insult, age, sex, lifestyle, genetic risk factors, socioeconomic status, other co-injuries, and underlying health problems. This review discusses the genes that have been directly tested in TBI models, and whether their effects are known to be sex-dependent. Sex differences can affect the incidence, symptom onset, pathology, and clinical outcomes following injury. Adult males are more susceptible at the acute phase and females sh..View full abstract
Awarded by National Health and Medical Research Council of Australia
Funding was received from the National Health and Medical Research Council of Australia (Grant No. APP1120583) to RC and PJC.