Journal article

A novel rat model of heterotopic ossification after polytrauma with traumatic brain injury

Rhys D Brady, Michael Z Zhao, Ker R Wong, Pablo M Casilla-Espinosa, Glenn R Yamakawa, Ryan C Wortman, Mujun Sun, Brian L Grills, Richelle Mychasiuk, Terence J O'Brien, Denes Agoston, Peter VS Lee, Stuart J McDonald, Dale L Robinson, Sandy R Shultz

Bone | ELSEVIER SCIENCE INC | Published : 2020


Neurological heterotopic ossification (NHO) is characterized by abnormal bone growth in soft tissue and joints in response to injury to the central nervous system. The ectopic bone frequently causes pain, restricts mobility, and decreases the quality of life for those affected. NHO commonly develops in severe traumatic brain injury (TBI) patients, particularly in the presence of concomitant musculoskeletal injuries (i.e. polytrauma). There are currently no animal models that accurately mimic these combinations of injuries, which has limited our understanding of NHO pathobiology, as well as the development of biomarkers and treatments, in TBI patients. In order to address this shortcoming, he..

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Awarded by NHMRC ECR Fellowship

Funding Acknowledgements

This study was funded by a grant to RDB from Monash University, and a fellowship from the Australian National Health and Medical Research Council (NHMRC) to SRS. PMCE was funded by a NHMRC ECR Fellowship (#APP1166170). The authors would like to acknowledge Paul S. Hood, Stephen K. Hood and Michael A. Ryan for their assistance in constructing the injury device use to administer the muscle crush and fracture.