Developmental divergence of structural brain networks as an indicator of future cognitive impairments in childhood brain injury: Executive functions
Daniel J King, Stefano Seri, Richard Beare, Cathy Catroppa, Vicki A Anderson, Amanda G Wood
Developmental Cognitive Neuroscience | ELSEVIER SCI LTD | Published : 2020
Brain insults during childhood can perturb the already non-linear trajectory of typical brain maturation. The diffuse effects of injury can be modelled using structural covariance networks (SCN), which change as a function of neurodevelopment. However, SCNs are estimated at the group-level, limiting applicability to predicting individual-subject outcomes. This study aimed to measure the divergence of the brain networks in paediatric traumatic brain injury (pTBI) patients and controls, and investigate relationships with executive functioning (EF) at 24 months post-injury. T1-weighted MRI acquired acutely in 78 child survivors of pTBI and 33 controls underwent 3D-tissue segmentation to estimat..View full abstract
Awarded by European Research Council (ERC) Consolidator Grant (ERC-CoG)
This work was supported by a European Research Council (ERC) Consolidator Grant (ERC-CoG) to AW [grant number 682734]. DK was supported by a studentship from Aston University, School of Life and Health Sciences.