Recent advances in functional research in Giardia intestinalis
Aaron R Jex, Staffan Svard, Kari D Hagen, Hannah Starcevich, Samantha J Emery-Corbin, Balu Balan, Chris Nosala, Scott C Dawson
Advances in Parasitology- Vol 107 : Giardia and Giardiasis - Part B | Advances in Parasitology | ELSEVIER ACADEMIC PRESS INC | Published : 2020
This review considers current advances in tools to investigate the functional biology of Giardia, it's coding and non-coding genes, features and cellular and molecular biology. We consider major gaps in current knowledge of the parasite and discuss the present state-of-the-art in its in vivo and in vitro cultivation. Advances in in silico tools, including for the modelling non-coding RNAs and genomic elements, as well as detailed exploration of coding genes through inferred homology to model organisms, have provided significant, primary level insight. Improved methods to model the three-dimensional structure of proteins offer new insights into their function, and binding interactions with li..View full abstract
Awarded by Australian National Health and Medical Research Council
A.J. acknowledges funding support from the Australian National Health and Medical Research Council (Career Development Fellowship APP1126395), Melbourne Water and the Victorian State Government Operational Infrastructure Support and Australian Government National Health and Medical Research Council Independent Research Institute Infrastructure Support Scheme.