Source-level Cortical Power Changes for Xenon and Nitrous Oxide-induced Reductions in Consciousness in Healthy Male Volunteers
Andria Pelentritou, Levin Kuhlmann, John Cormack, Will Woods, Suresh Muthukumaraswamy, David Liley
Anesthesiology | LIPPINCOTT WILLIAMS & WILKINS | Published : 2020
BACKGROUND: Investigations of the electrophysiology of gaseous anesthetics xenon and nitrous oxide are limited revealing inconsistent frequency-dependent alterations in spectral power and functional connectivity. Here, the authors describe the effects of sedative, equivalent, stepwise levels of xenon and nitrous oxide administration on oscillatory source power using a crossover design to investigate shared and disparate mechanisms of gaseous xenon and nitrous oxide anesthesia. METHODS: Twenty-one healthy males underwent simultaneous magnetoencephalography and electroencephalography recordings. In separate sessions, sedative, equivalent subanesthetic doses of gaseous anesthetic agents nitrous..View full abstract
Awarded by James S. McDonnell collaborative grant
Supported by a James S. McDonnell collaborative grant No. 220020419 "Reconstructing Consciousness and Cognition, Phase 2" awarded to George Mashour, Michael Avidan, Max Kelz, and David Liley.