Journal article

Spatial Properties of Reactive Oxygen Species Govern Pathogen-Specific Immune System Responses

Eunice E To, John J O'Leary, Luke AJ O'Neill, Ross Vlahos, Steven Bozinovski, Christopher JH Porter, Robert D Brooks, Doug A Brooks, Stavros Selemidis

Antioxidants and Redox Signaling | MARY ANN LIEBERT, INC | Published : 2020

Abstract

Significance: Reactive oxygen species (ROS) are often considered to be undesirable toxic molecules that are generated under conditions of cellular stress, which can cause damage to critical macromolecules such as DNA. However, ROS can also contribute to the pathogenesis of cancer and many other chronic inflammatory disease conditions, including atherosclerosis, metabolic disease, chronic obstructive pulmonary disease, neurodegenerative disease, and autoimmune disease. Recent Advances: The field of ROS biology is expanding, with an emerging paradigm that these reactive species are not generated haphazardly, but instead produce..

View full abstract