Journal article

Cancer LncRNA Census reveals evidence for deep functional conservation of long noncoding RNAs in tumorigenesis

Joana Carlevaro-Fita, Andres Lanzos, Lars Feuerbach, Chen Hong, David Mas-Ponte, Jakob Skou Pedersen, Rory Johnson, Federico Abascal, Samirkumar B Amin, Gary D Bader, Jonathan Barenboim, Rameen Beroukhim, Johanna Bertl, Keith A Boroevich, Soren Brunak, Peter J Campbell, Joana Carlevaro-Fita, Dimple Chakravarty, Calvin Wing Yiu Chan, Ken Chen Show all

Communications Biology | NATURE PUBLISHING GROUP | Published : 2020


Funding Acknowledgements

We wish to thanks Julien Lagarde (CRG) for help and advice in bioinformatic analysis. We acknowledge Romina Garrido (CRG), Deborah Re (DBMR), Silvia Roesselet (DBMR) and Marianne Zahn (Inselspital) for administrative support. We thank Ivo Buchhalter (DKFZ) and Sandra Koser (DKFZ) for preprocessing the SNV and expression data for the integrated analysis. Inigo Martincorena (Sanger Institute) kindly provided the script for analysing driver prediction sensitivity. A.L. was supported by pre-doctoral fellowship FPU14/03371. This research was supported by the Swiss National Science Foundation through the National Centres for Competence in Research "RNA & Disease", and by the Department of Medical Oncology of Inselspital. We acknowledge the contributions of the many clinical networks across ICGC and TCGA who provided samples and data to the PCAWG Consortium, and the contributions of the Technical Working Group and the Germline Working Group of the PCAWG Consortium for collation, realignment and harmonised variant calling of the cancer genomes used in this study. We thank the patients and their families for their participation in the individual ICGC and TCGA projects.