Journal article

What has been the impact of new drug treatments on epilepsy?

Zhibin Chen, Martin J Brodie, Patrick Kwan

Current Opinion in Neurology | LIPPINCOTT WILLIAMS & WILKINS | Published : 2020


PURPOSE OF REVIEW: Nearly two dozen antiseizure medications (ASMs) with different mechanisms of action have been introduced over the past three decades with the aim of providing better efficacy or safety profile than the previous drugs. Several new ASMs with improvement on a classic drug family or have novel mechanisms of action have been recently approved for epilepsy. The present review explored recent studies or guidelines on new agents and discussed the potential impact of these novel treatments on epilepsy management and future directions of research. RECENT FINDINGS: Long-term cohort studies showed that, collectively, the second-generation did not improve the overall prognosis of epile..

View full abstract


Funding Acknowledgements

Z.C. was supported by the NHMRC Early Career Fellowship, and has received research grants from University of Melbourne Early Career Researcher Grant Scheme. P.K. is supported by the Medical Research Future Fund Practitioner Fellowship.