Journal article

The INTERNET STUDY: A phase II study of everolimus in patients with fluorodeoxyglucose (F-18) positron-emission tomography positive intermediate grade pancreatic neuroendocrine tumors

Mei Sim Lung, Rodney J Hicks, Nick Pavlakis, Emma Link, Michael Jefford, Benjamin Thomson, David K Wyld, Winston Liauw, Timothy Akhurst, Narmatha Kuru, Michael Michael

ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY | WILEY | Published : 2020

Abstract

AIMS: This multicenter phase II trial evaluates the efficacy of everolimus in poor prognosis grade 2 (G2) pancreatic neuroendocrine tumors (PNETs), defined by 2-[fluorine-18]fluoro-2-deoxy-d-glucose (FDG) positron-emission tomography (PET) avidity. FDG-PET avidity in NETs is associated with a significantly higher risk of death, outperforming Ki-67 index or liver metastases as a poor prognostic factor. We hypothesized that everolimus has efficacy in patients with FDG-PET-avid G2 PNETs and prospectively evaluated progression-free survival (PFS) and response in the first-line setting. METHODS: Patients with FDG-PET-avid G2 advanced PNET received everolimus 10 mg daily until disease progression...

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