Journal article
EZH2 function in immune cell development
Stephen L Nutt, Christine Keenan, Michael Chopin, Rhys S Allan
BIOLOGICAL CHEMISTRY | WALTER DE GRUYTER GMBH | Published : 2020
Abstract
The polycomb repressive complex 2 (PRC2) consists of three core components EZH2, SUZ12 and EED. EZH2 catalyzes the methylation of lysine 27 of histone H3, a modification associated with gene silencing. Through gene duplication higher vertebrate genomes also encode a second partially redundant methyltransferase, EZH1. Within the mammalian immune system most research has concentrated on EZH2 which is expressed predominantly in proliferating cells. EZH2 and other PRC2 components are required for hematopoietic stem cell function and lymphocyte development, at least in part by repressing cell cycle inhibitors. At later stages of immune cell differentiation, EZH2 plays essential roles in humoral a..
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Awarded by National Health and Medical Research Council of Australia
Funding Acknowledgements
This work was supported by grants and fellowships from the National Health and Medical Research Council of Australia (1049307, 1125436, 1155342, Funder Id: http://dx.doi.org/10.13039/501100000925) and an American Asthma Foundation Senior Award.