Epimimetics: Novel Therapeutics Targeting Epigenetic Mediators and Modulators
Anthony J Hannan
Trends in Pharmacological Sciences | ELSEVIER SCIENCE LONDON | Published : 2020
Epigenetic alterations have been associated with a wide range of diseases. Furthermore, many therapeutic interventions modelling environmental exposures appear to involve epigenetic mechanisms. Recent progress has been made in developing drugs targeting specific epigenetic components. Here, I propose developing 'epimimetics', novel drugs that mimic or enhance therapeutic effects of epigenetic modifications.
I thank members of the Hannan Laboratory, past and present, who have contributed experimental data and analyses that have informed these ideas. My research is supported by a Principal Research Fellowship and Project Grants from the National Health and Medical Research Council (NHMRC) and Discovery Project funding from the Australian Research Council (ARC), as well as the DHB Foundation, Equity Trustees.