Awake functional MRI detects neural circuit dysfunction in a mouse model of autism
Tomokazu Tsurugizawa, Kota Tamada, Nobukazu Ono, Sachise Karakawa, Yuko Kodama, Clement Debacker, Junichi Hata, Hideyuki Okano, Akihiko Kitamura, Andrew Zalesky, Toru Takumi
SCIENCE ADVANCES | AMER ASSOC ADVANCEMENT SCIENCE | Published : 2020
MRI has potential as a translational approach from rodents to humans. However, given that mouse functional MRI (fMRI) uses anesthetics for suppression of motion, it has been difficult to directly compare the result of fMRI in "unconsciousness" disease model mice with that in "consciousness" patients. We develop awake fMRI to investigate brain function in 15q dup mice, a copy number variation model of autism. Compared to wild-type mice, we find that 15q dup is associated with whole-brain functional hypoconnectivity and diminished fMRI responses to odors of stranger mice. Ex vivo diffusion MRI reveals widespread anomalies in white matter ultrastructure in 15q dup mice, suggesting a putative an..View full abstract
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Awarded by KAKENHI
Awarded by Australian National Health and Medical Research Council (NHMRC)
This work was funded by Ajinomoto Co. Inc.; KAKENHI Grant-in-Aid for Young Scientists, Scientific Research (S), and Scientific Research on Innovative Areas (16H06316, 16H06463, and 24700380); JST CREST; and the Takeda Science Foundation and Smoking Science Foundation. A.Z. was supported by the Australian National Health and Medical Research Council (NHMRC) Senior Research Fellowship B (ID: 1136649).