Is Peripheral BDNF Promoter Methylation a Preclinical Biomarker of Dementia?
Peter D Fransquet, Karen Ritchie, Vania Januar, Richard Saffery, Marie-Laure Ancelin, Joanne Ryan
JOURNAL OF ALZHEIMERS DISEASE | IOS PRESS | Published : 2020
Brain-derived neurotrophic factor (BDNF) has been implicated in dementia. Preliminary evidence suggests that BDNF DNA methylation may be a diagnostic biomarker of dementia, but the potential pre-clinical utility remains unclear. Participants in the ESPRIT study were assessed for cognitive function and dementia (DSM-IV criteria) over 14 years. BDNF exon 1 promoter methylation was measured in blood at baseline (n = 769) and buccal samples during follow-up (n = 1062). Genotyping was carried out for several common BDNF SNPs, including Val66Met (rs6265) and APOE ɛ4. Multivariable logistic regression analyses determined the association between BDNF methylation and both prevalent and incident demen..View full abstract
Awarded by Agence Nationale de la Recherche Project
Awarded by Dementia Research Leader fellowship (National Health & Medical Research Council (NHMRC), Australia)
Awarded by Laboratoire d'Analyse Genomique - Centre de Ressources Biologiques (LAG-CRB) - Institut Pasteur de Lille, France
The authors acknowledge the Laboratoire d'Analyse Genomique - Centre de Ressources Biologiques (LAG-CRB) - BB-0033-00071 Institut Pasteur de Lille, F-59000 Lille, France for managing human samples. The authors would also like to acknowledge Dr. Audrey Gabelle, Memory Research and Resources Center, Department of Neurology, CHU Montpellier, Montpellier, France for her role if validating the dementia diagnosis. The ESPRIT project is financed by the regional government of Languedoc-Roussillon, the Agence Nationale de la Recherche Project 07 LVIE 004, and an unconditional grant from Novartis. This work was also supported by France Alzheimer. The funders had no role in the design and conduct of the study; in data collection, management, analysis or interpretation of the data and were not involved with the writing, preparation, review or approval of the manuscript. PF is funded by RTP stipend PhD scholarship, awarded by Monash University and the Australian Government. JR is funded by a Dementia Research Leader fellowship (APP1135727 from the National Health & Medical Research Council (NHMRC), Australia.