Risk of Intracranial Hemorrhage Following Intravenous tPA (Tissue-Type Plasminogen Activator) for Acute Stroke Is Low in Children.
Catherine Amlie-Lefond, Dennis WW Shaw, Andrew Cooper, Mark S Wainwright, Adam Kirton, Ryan J Felling, Michael G Abraham, Mark T Mackay, Michael M Dowling, Marcela Torres, Michael J Rivkin, Eric F Grabowski, Sarah Lee, Jonathan E Kurz, Hugh J McMillan, Dwight Barry, Jacqueline Lee-Eng, Rebecca N Ichord
Stroke | Published : 2020
Background and Purpose- Data regarding the safety and efficacy of intravenous tPA (tissue-type plasminogen activator) in childhood acute arterial ischemic stroke are inadequate. The TIPS trial (Thrombolysis in Pediatric Stroke; National Institutes of Health grant R01NS065848)-a prospective safety and dose-finding trial of intravenous tPA in acute childhood stroke-was closed for lack of accrual. TIPS sites have subsequently treated children with acute stroke in accordance with established institutional protocols supporting data collection on outcomes. Methods- Data on children treated with intravenous tPA for neuroimaging-confirmed arterial ischemic stroke were collected retrospectively from ..View full abstract