Thrombin dynamics in children with liver disease or extrahepatic portal vein obstruction or shunt

W Beattie; R Kremers; M Magnusson; T Peters; B de Laat; W Hardikar; P Monagle; V Ignjatovic

Journal article

Thrombin dynamics in children with liver disease or extrahepatic portal vein obstruction or shunt

W Beattie, R Kremers, M Magnusson, T Peters, B de Laat, W Hardikar, P Monagle, V Ignjatovic

Thrombosis Research | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2020

DOI: 10.1016/j.thromres.2020.02.008

Abstract

Introduction: Changes in the coagulation profile in children with liver disease and extrahepatic portal vein obstruction or shunt result in both bleeding and thrombosis. Routine coagulation tests do not accurately predict bleeding risk, as they are not sensitive to changes in anticoagulant factors. The thrombin generation assay could be suitable for describing the overall balance of coagulation in children with liver disease. This study aims to characterise the mechanism of thrombin generation in this population, focusing on prothrombin conversion and thrombin inhibition. Methods: Patients were categorised as: severe (paediatric end stage liver disease score > 15) and mild disease, or portal..

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University of Melbourne Researchers

Paul Monagle Author

Vera Ignjatovic Author

Grants

Funding Acknowledgements

The authors would like to thank Diagnostica Stago for providing the laboratory reagents and for the loan of the analyser used for TGA. This study was supported by the Murdoch Childrens Research Institute theme funding program.