Journal article

Cardiovascular mortality following liver transplantation: predictors and temporal trends over 30 years

Anoop N Koshy, Paul J Gow, Hui-Chen Han, Andrew W Teh, Robert Jones, Adam Testro, Han S Lim, Geoffrey McCaughan, Gary P Jeffrey, Michael Crawford, Graeme Macdonald, Jonathan Fawcett, Alan Wigg, John WC Chen, Edward J Gane, Stephen R Munn, David J Clark, Matias B Yudi, Omar Farouque

European Heart Journal - Quality of Care and Clinical Outcomes | OXFORD UNIV PRESS | Published : 2020

Abstract

AIMS: There has been significant evolution in operative and post-transplant therapies following liver transplantation (LT). We sought to study their impact on cardiovascular (CV) mortality, particularly in the longer term. METHODS AND RESULTS: A retrospective cohort study was conducted of all adult LTs in Australia and New Zealand across three 11-year eras from 1985 to assess prevalence, modes, and predictors of early (≤30 days) and late (>30 days) CV mortality. A total of 4265 patients were followed-up for 37 409 person-years. Overall, 1328 patients died, and CV mortality accounted for 228 (17.2%) deaths. Both early and late CV mortality fell significantly across the eras (P < 0.001). Howev..

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Grants

Funding Acknowledgements

A.N.K. is a recipient of the National Health andMedical Research Council of Australia/National Heart Foundation Post-Graduate Scholarship and Royal Australasian College of Physicians Blackburn Scholarship. A.W.T. is a recipient of the Early Career Fellowship from the National Health and Medical Research Council of Australia.