Journal article

Diagnostic Accuracy of Prion Disease Biomarkers in Iatrogenic Creutzfeldt-Jakob Disease

Franc Llorens, Anna Villar-Pique, Peter Hermann, Matthias Schmitz, Olga Calero, Christiane Stehmann, Shannon Sarros, Fabio Moda, Isidre Ferrer, Anna Poleggi, Maurizio Pocchiari, Marcella Catania, Sigrid Klotz, Carl O'Regan, Francesca Brett, Josephine Heffernan, Anna Ladogana, Steven J Collins, Miguel Calero, Gabor G Kovacs Show all

Biomolecules | MDPI | Published : 2020

Abstract

Human prion diseases are classified into sporadic, genetic, and acquired forms. Within this last group, iatrogenic Creutzfeldt-Jakob disease (iCJD) is caused by human-to-human transmission through surgical and medical procedures. After reaching an incidence peak in the 1990s, it is believed that the iCJD historical period is probably coming to an end, thanks to lessons learnt from past infection sources that promoted new prion prevention and decontamination protocols. At this point, we sought to characterise the biomarker profile of iCJD and compare it to that of sporadic CJD (sCJD) for determining the value of available diagnostic tools in promptly recognising iCJD cases. To that end, we co..

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Grants

Awarded by Instituto Carlos III


Awarded by Fundacio La Marato de TV3


Awarded by Robert Koch Institute through funds from the Federal Ministry of Health


Awarded by NHMRC Practitioner Fellowship


Funding Acknowledgements

This research was funded by the Instituto Carlos III (grants CP/00041 and PI19/00144) and by the Fundacio La Marato de TV3 (201821-30-31-32) to FL and by the Robert Koch Institute through funds from the Federal Ministry of Health (grant No, 1369-341) to IZ. This project was also funded at 65% by the Fondo Europeo de Desarrollo Regional (FEDER) through the Interreg V-A Espana-Francia-Andorra (POCTEFA 2014-2020) programme. SJC is funded in part by a NHMRC Practitioner Fellowship (identification #APP1105784).