Journal article

Calcineurin A Is Essential in the Regulation of Asexual Development, Stress Responses and Pathogenesis in Talaromyces marneffei

Yan-Qing Zheng, Kai-Su Pan, Jean-Paul Latge, Alex Andrianopoulos, Hong Luo, Ru-Fan Yan, Jin-Ying Wei, Chun-Yang Huang, Cun-Wei Cao

FRONTIERS IN MICROBIOLOGY | FRONTIERS MEDIA SA | Published : 2020

Abstract

Talaromyces marneffei is a common cause of infection in immunocompromised patients in Southeast Asia and Southern China. The pathogenicity of T. marneffei depends on the ability of the fungus to survive the cytotoxic processes of the host immune system and grow inside host macrophages. These mechanisms that allow T. marneffei to survive macrophage-induced death are poorly understood. In this study, we examined the role of a calcineurin homolog (cnaA) from T. marneffei during growth, morphogenesis and infection. Deletion of the cnaA gene in T. marneffei resulted in a strain with significant defects in conidiation, germination, morphogenesis, cell wall integrity, and resistance to various stre..

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University of Melbourne Researchers

Grants

Awarded by National Natural Science Foundation of China


Awarded by Natural Science Foundation of Guangxi Province of China


Funding Acknowledgements

This study was supported by grants from the National Natural Science Foundation of China (Nos. 81571971 and 81271804) and the Natural Science Foundation of Guangxi Province of China (AB18221017 and 2018GXNSFAA294090). The funders had no role in the study design, data collection and analysis, decision to publish or preparation of the manuscript.