Journal article

The effect of stimulus strength on binocular rivalry rate in healthy individuals: Implications for genetic, clinical and individual differences studies

Phillip CF Law, Steven M Miller, Trung T Ngo

PHYSIOLOGY & BEHAVIOR | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2017

Abstract

Binocular rivalry (BR) occurs when conflicting images concurrently presented to corresponding retinal locations of each eye stochastically alternate in perception. Anomalies of BR rate have been examined in a range of clinical psychiatric conditions. In particular, slow BR rate has been proposed as an endophenotype for bipolar disorder (BD) to improve power in large-scale genome-wide association studies. Examining the validity of BR rate as a BD endophenotype however requires large-scale datasets (n=1000s to 10,000s), a standardized testing protocol, and optimization of stimulus parameters to maximize separation between BD and healthy groups. Such requirements are indeed relevant to all clin..

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Grants

Awarded by National Health and Medical Research Council


Awarded by NARSAD Young Investigator Grant from Brain & Behavior Research Foundation, USA


Funding Acknowledgements

We thank all volunteers who participated in the study and an anonymous reviewer for helpful comments on an earlier version of this manuscript. TTN was supported by National Health and Medical Research Council [grant number 490976]. SMM received support from National Health and Medical Research Council, Defence Health Foundation, a 2012 NARSAD Young Investigator Grant from Brain & Behavior Research Foundation, USA) [grant number 19163], and Monash Institute of Medical Engineering.