Journal article

Personality polygenes, positive affect, and life satisfaction

A Weiss, BML Baselmans, E Hofer, J Yang, A Okbay, PA Lind, MB Miller, IM Nolte, W Zhao, SP Hagenaars, JJ Hottenga, LK Matteson, H Snieder, JD Faul, CA Hartman, PA Boyle, H Tiemeier, MA Mosing, A Pattie, G Davies Show all

Twin Research and Human Genetics | CAMBRIDGE UNIV PRESS | Published : 2016

Open access

Abstract

Approximately half of the variation in wellbeing measures overlaps with variation in personality traits. Studies of non-human primate pedigrees and human twins suggest that this is due to common genetic influences. We tested whether personality polygenic scores for the NEO Five-Factor Inventory (NEO-FFI) domains and for item response theory (IRT) derived extraversion and neuroticism scores predict variance in wellbeing measures. Polygenic scores were based on published genome-wide association (GWA) results in over 17,000 individuals for the NEO-FFI and in over 63,000 for the IRT extraversion and neuroticism traits. The NEO-FFI polygenic scores were used to predict life satisfaction in 7 coho..

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University of Melbourne Researchers

Grants

Awarded by European Commission


Funding Acknowledgements

[ "We thank the study participants and the support staff involved in participant recruitment, phenotype collection, genotyping, data management and processing. Individual study acknowledgements can be found in the online Supplementary material. ASPS: The research reported in this article was funded by the Austrian Science Fond (FWF) grant numbers P20545 -P05 and P13180. The Medical University of Graz supports the databank of the ASPS. HRS is supported by the National Institute on Aging (NIA U01AG009740). The genotyping was funded separately by the National Institute on Aging (RC2 AG036495, RC4 AG039029). LBC1921: Phenotype collection was supported by the UK's Biotechnology and Biological Sciences Research Council (BBSRC), the Royal Society, and the Chief Scientist Office of the Scottish Government. Genotyping was funded by the BBSRC. The work was undertaken by the University of Edinburgh Centre for Cognitive Ageing and Cognitive Epidemiology; part of the cross council Lifelong Health and Wellbeing Initiative (MR/K026992/1). Funding from the BBSRC and Medical Research Council (MRC) is gratefully acknowledged. Lifelines Cohort Study: The Lifelines Cohort Study, and generation and management of GWAS genotype data for the Lifelines Cohort Study is supported by the Netherlands Organization of Scientific Research NWO (grant 175.010.2007.006), the Economic Structure Enhancing Fund (FES) of the Dutch government, the Ministry of Economic Affairs, the Ministry of Education, Culture and Science, the Ministry for Health, Welfare and Sports, the Northern Netherlands Collaboration of Provinces (SNN), the Province of Groningen, University Medical Center Groningen, the University of Groningen, Dutch Kidney Foundation and Dutch Diabetes Research Foundation. NTR: This work was supported by the Netherlands Organization for Scientific Research (NWO: MagW/ZonMW grants 904-61-090, 985-10-002,904-61-193,480-04-004, 400-05-717, NOW-bilareral agreement 463-06-001, NWO-VENI 451-04-034, Addiction-31160008 Middelgroot-911-09-032, Spinozapremie 56-464-14192), Biobanking and Biomolecular Resources Research Infrastructure (BBMRI; NL, 184.021.007), the VU University's Institute for Health and Care Research (EMGO+) and Neuroscience Campus Amsterdam (NCA), the European Science Council (ERC Advanced, 230374), the Avera Institute for Human Genetics, Sioux Falls, South Dakota (USA) and the National Institutes of Health (NIH, R01D0042157-01A). Part of the genotyping was funded by the Genetic Association Information Network (GAIN) of the Foundation for the US National Institutes of Health (NIMH, MH081802) and by the Grand Opportunity grants 1RC2C2MH089951-01 and 1RC2 MH089995-01 from the NINTH. Part of the analyses (for RS & TRAILS, too) were carried out on the Genetic Cluster Computer (http://www.geneticcluster.org), which is financially supported by the Netherlands Scientific Organization (NWO 480-05-003), the Dutch Brain Foundation, and the Department of Psychology and Education of the VU University Amsterdam. M. Bartels is/was financially supported by a senior fellowship of the (EMGO+) Institute for Health and Care and a VU University Research Chair position. MCTFR: Research reported in this publication was supported by the National Institutes of Health under award numbers R37DA005147, R01AA009367, R01AA011886, R01DA013240, R01MH066140, and U01DA024417. QIMRB: Funding was provided by the Australian NHMRC (241944, 339462, 389927, 389875, 389891, 389892, 389938, 442915, 442981, 496739, 552485, 552498, 613608), the FP-5 GenomEUtwin Project (QLG2-CT-2002-01254), and the U.S.", "r NIH grants (AA07535, AA10248, AA13320, AA13321, AA13326, AA14041, M1166206). RS: The generation and management of GWAS genotype data for the Rotterdam Study is supported by the Netherlands Organisation of Scientific Research NWO Investments (nr. 175.010.2005.011, 911-03-012). This study is funded by the Research Institute for Diseases in the Elderly (014-93-015; RIDE2), the Netherlands Genomics Initiative (NGI)/Netherlands Organisation for Scientific Research (NWO) project no. 050-060-810. The Rotterdam Study is funded by Erasmus Medical Center and Erasmus University, Rotterdam, Netherlands Organization for the Health Research and Development (ZonMw), the Research Institute for Diseases in the Elderly (RIDE), the Ministry of Education, Culture and Science, the Ministry for Health, Welfare and Sports, the European Commission (DG XII), and the Municipality of Rotterdam. STR: The Jan Wallander and Torn Hedelius Foundation (P2012-0002:1), the Ragnar Soderberg Foundation (E9/11), The Swedish Research Council (421-2013-1061), the Ministry for Higher Education, The Swedish Research Council (M-2205-1112), GenomEUtwin (EU/QLRT-2001-01254; QLG2-CT-2002-01254), NIH DK U01-066134, the Swedish Foundation for Strategic Research (SSF). The Rush Memory and Aging Project is supported by NIA grants R01AG15819 and R01AG17917, and the Translational Genomics Research Institute. TRAILS has been financially supported by various grants from the Netherlands Organization for Scientific Research NWO (Medical Research Council program grant GB-MW 940-38-011; ZonMW Brainpower grant 100-001-004; ZonMw Risk Behavior and Dependence grants 60-60600-97118; ZonMw Culture and Health grant 261-98-710; Social Sciences Council medium-sized investment grants GB-MaGIAT 480-01-006 and GB-MaGW 480-07-001; Social Sciences Council project grants GB-MaGW 452-04-314 and GB-MaGNV 452-06-004; NWO large -sized investment grant 175.010.2003.005; NWO Longitudinal Survey and Panel Funding 481-08-013 and 481-11-001), the Dutch Ministry of Justice (WODC), the European Science Foundation (EuroSTRESS project FP-006), Biobanking and Biomolecular Resources Research Infrastructure BBMRI-NL (CP 32), and the participating universities. YFS: Has been financially supported by the Academy of Finland (grants 126925, 121584, 124282, 129378 (Salve), 117787 (Gendi), 41071 (Skidi), and 265869 (Mind)), the Social Insurance Institution of Finland, Kuopio, Tampere and Turku University Hospital Medical Funds (grant 9N035 for Dr. Lehtimaki), Julio Vainio Foundation, Paavo Nurmi Foundation, Finnish Foundation of Cardiovascular Research and Finnish Cultural Foundation, Tampere Tuberculosis Foundation and Emil Aaltonen Foundation (for Dr. Lehtimaki)." ]