Journal article

Neuroticism as a Predictor of Frailty in Old Age: A Genetically Informative Approach

Hilda Bjork Danielsdottir, Juulia Jylhava, Sara Hagg, Yi Lu, Lucia Colodro-Conde, Nicholas G Martin, Nancy L Pedersen, Miriam A Mosing, Kelli Lehto



OBJECTIVE: Neuroticism is associated with poor health outcomes, but its contribution to the accumulation of health deficits in old age, that is, the frailty index, is largely unknown. We aimed to explore associations between neuroticism and frailty cross-sectionally and longitudinally, and to investigate the contribution of shared genetic influences. METHODS: Data were derived from the UK Biobank (UKB; n = 274,951), the Australian Over 50's Study (AO50; n = 2849), and the Swedish Twin Registry (Screening Across the Lifespan of Twins Study [SALT], n = 18,960; The Swedish Adoption/Twin Study of Aging [SATSA], n = 1365). Associations between neuroticism and the frailty index were investigated u..

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Awarded by Swedish FORTE

Awarded by Swedish Research Council

Awarded by Loo and Hans Osterman Foundation for Medical Research

Awarded by programme Mobilitas Pluss

Funding Acknowledgements

This work was supported by research grants from Swedish FORTE (grant number 2013-2292 to N.L.P.), the Swedish Research Council (grant numbers 521-2013-8689 and 2015-03255 to N.L.P.), Loo and Hans Osterman Foundation for Medical Research (grant number 2017-00103 to K.L., grant number 2018-0004 to M.A.M., grant number 2017-00108 to J.J.), and the Strategic Research Program in Epidemiology at Karolinska Institutet (to J.J., S.H.). K.L. is supported by European Regional Development Fund and the programme Mobilitas Pluss (grant number MOBTP142). L.C.-C. is supported by a QIMR Berghofer fellowship. The authors have no conflict of interests to declare.