Journal article
A genome-wide association study of self-rated health
MA Mosing, KJH Verweij, SE Medland, J Painter, SD Gordon, AC Heath, PA Madden, GW Montgomery, NG Martin
Twin Research and Human Genetics | CAMBRIDGE UNIV PRESS | Published : 2010
Abstract
Self-rated health questions have been proven to be a highly reliable and valid measure of overall health as measured by other indicators in many population groups. It also has been shown to be a very good predictor of mortality, chronic or severe diseases, and the need for services, and is positively correlated with clinical assessments. Genetic factors have been estimated to account for 25-64% of the variance in the liability of self-rated health. The aim of the present study was to identify Single Nucleotide Polymorphisms (SNPs) underlying the heritability of self-rated health by conducting a genome-wide association analysis in a large sample of 6,706 Australian individuals aged 18-92. No ..
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Awarded by National Institutes of Health
Funding Acknowledgements
We would like to thank the twins and their families registered at the ATR for their participation and QIMR for sample collection. Funding was provided by the Australian NHMRC (241944, 339462, 389927, 389875, 389891, 389892, 389938, 442915, 442981, 496739, 552485, 552498, 613608), the FP-5 GenomEUtwin Project (QLG2-CT-2002-01254), and the U.S. NIH grants (AA07535, AA10248, AA13320, AA13321, AA13326, AA14041, MH66206). MAM and KJHV are supported by ANZ Trustees PhD scholarships in Medical Research. SEM is supported by an NHMRC Sidney Sax fellowship.