Gut microbiota composition during infancy and subsequent behavioural outcomes
Amy Loughman, Anne-Louise Ponsonby, Martin O'Hely, Christos Symeonides, Fiona Collier, Mimi LK Tang, John Carlin, Sarath Ranganathan, Katrina Allen, Angela Pezic, Richard Saffery, Felice Jacka, Leonard C Harrison, Peter D Sly, Peter Vuillermin
EBioMedicine | ELSEVIER | Published : 2020
BACKGROUND: Despite intense interest in the relationship between gut microbiota and brain development, longitudinal data from human studies are lacking. This study aimed to investigate the relationship between the composition of gut microbiota during infancy and subsequent behavioural outcomes. METHODS: A subcohort of 201 children with behavioural outcome measures was identified within a longitudinal, Australian birth-cohort study. The faecal microbiota were analysed at 1, 6, and 12 months of age. Behavioural outcomes were measured at 2 years of age. FINDINGS: In an unselected birth cohort, we found a clear association between decreased normalised abundance of Prevotella in faecal samples co..View full abstract
Awarded by National Health and Medical Research Council of Australia
This study was funded by the National Health and Medical Research Council of Australia (1082307, 1147980, 1129813), The Murdoch Children's Research Institute, Barwon Health, Deakin University, Perpetual Trustees, and The Shepherd Foundation. The funders had no involvement in the data collection, analysis or interpretation, trial design, recruitment or any other aspect pertinent to the study.