Journal article

Systemic administration of pentoxifylline attenuates the development of hypertension in renovascular hypertensive rats

Anthony Setiadi, Willian S Korim, Clive N May, Song T Yao

Hypertension Research | Springer Nature | Published : 2020

Abstract

There is evidence to suggest that hypertension involves a chronic low-grade systemic inflammatory response; however, the underlying mechanisms are unclear. To further understand the role of inflammation in hypertension, we used a rat renovascular model of hypertension in which we administered the TNF-α synthesis inhibitor pentoxifylline (PTX, 30 mg/kg/day) in the drinking water for 60 days. In conscious rats, PTX administration significantly attenuated the development of hypertension (systolic blood pressure, PTX: 145 ± 8 vs. vehicle (Veh): 235 ± 11 mmHg, after 38 days of treatment, P < 0.05, N = 5/group). This attenuation in hypertension was coupled with a decrease in the low-frequency spec..

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Grants

Awarded by National Health and Medical Research Council of Australia


Awarded by Australian Research Council Future Fellowship


Funding Acknowledgements

This work was supported by the National Health and Medical Research Council of Australia (GNT 1079680 to STY and GNT 1128108 to CMN and STY), the High Blood Pressure Research Council of Australia and the Rebecca L Cooper Medical Foundation (to WSK). AS is supported by the Australian Government Research Training Program Scholarship. STY is supported by an Australian Research Council Future Fellowship (FT170100363).