Journal article

Brief asphyxial state following immediate cord clamping accelerates onset of left-to-right shunting across the ductus arteriosus after birth in preterm lambs

Joseph J Smolich, Kelly R Kenna, Michael MH Cheung, Jonathan P Mynard

Journal of Applied Physiology | AMER PHYSIOLOGICAL SOC | Published : 2020

Abstract

Reversal of shunting across the ductus arteriosus from right-to-left to left-to-right is a characteristic feature of the birth transition. Given that immediate cord clamping (ICC) followed by an asphyxial cord clamp-to-ventilation (CC-V) interval may augment left ventricular (LV) output and central blood flows after birth, we tested the hypothesis that an asphyxial CC-V interval accelerates the onset of postnatal left-to-right ductal shunting. High-fidelity central blood flow signals were obtained in anesthetized preterm lambs (gestation 128 ± 2 days) after ICC followed by a nonasphyxial (∼40 s, n = 9) or asphyxial (∼90 s, n = 9) CC-V interval before mechanical ventilation for 30 min after b..

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Grants

Awarded by National Heart Foundation of Australia (NHF)


Awarded by National Health and Medical Research Council of Australia (NHMRC)


Funding Acknowledgements

This work was supported by a Grant-in-Aid (G12M6372) from the National Heart Foundation of Australia (NHF), a Project Grant (1105137) from the National Health and Medical Research Council of Australia (NHMRC), and the Victorian Government's Operational Infrastructure Support Program. J. P. Mynard was supported by a cofunded Career Development Fellowship from the NHMRC and a Future Leader Fellowship from the NHF.