Brief asphyxial state following immediate cord clamping accelerates onset of left-to-right shunting across the ductus arteriosus after birth in preterm lambs
Joseph J Smolich, Kelly R Kenna, Michael MH Cheung, Jonathan P Mynard
Journal of Applied Physiology | AMER PHYSIOLOGICAL SOC | Published : 2020
Reversal of shunting across the ductus arteriosus from right-to-left to left-to-right is a characteristic feature of the birth transition. Given that immediate cord clamping (ICC) followed by an asphyxial cord clamp-to-ventilation (CC-V) interval may augment left ventricular (LV) output and central blood flows after birth, we tested the hypothesis that an asphyxial CC-V interval accelerates the onset of postnatal left-to-right ductal shunting. High-fidelity central blood flow signals were obtained in anesthetized preterm lambs (gestation 128 ± 2 days) after ICC followed by a nonasphyxial (∼40 s, n = 9) or asphyxial (∼90 s, n = 9) CC-V interval before mechanical ventilation for 30 min after b..View full abstract
Awarded by National Heart Foundation of Australia (NHF)
Awarded by National Health and Medical Research Council of Australia (NHMRC)
This work was supported by a Grant-in-Aid (G12M6372) from the National Heart Foundation of Australia (NHF), a Project Grant (1105137) from the National Health and Medical Research Council of Australia (NHMRC), and the Victorian Government's Operational Infrastructure Support Program. J. P. Mynard was supported by a cofunded Career Development Fellowship from the NHMRC and a Future Leader Fellowship from the NHF.