Randomised controlled trial to investigate the relationship between mild hypercapnia and cerebral oxygen saturation in patients undergoing major surgery
Clarence Wong, Leonid Churilov, Dean Cowie, Chong Oon Tan, Raymond Hu, David Tremewen, Brett Pearce, Param Pillai, Dharshi Karalapillai, Rinaldo Bellomo, Laurence Weinberg
BMJ Open | BMJ PUBLISHING GROUP | Published : 2020
OBJECTIVES: The effects of hypercapnia on regional cerebral oxygen saturation (rSO2) during surgery are unclear. We conducted a randomised controlled trial to investigate the relationship between mild hypercapnia and rSO2. We hypothesised that, compared with targeted normocapnia (TN), targeted mild hypercapnia (TMH) during major surgery would increase rSO2. DESIGN: A prospective, randomised, controlled trial in adult participants undergoing elective major surgery. SETTING: A single tertiary centre in Heidelberg, Victoria, Australia. PARTICIPANTS: 40 participants were randomised to either a TMH or TN group (20 to each). INTERVENTIONS: TMH (partial pressure of carbon dioxide in arterial blood,..View full abstract
Masimo provided the oximetry sensors used for this trial. This study conception, design, trial management, data collection, data analysis, and the writing of the manuscript, have been executed completely independently of Masimo and any other external organisations. This work was supported by the Deparment of Anaesthesia Research Fund, Austin Hospital, Heidelberg, Victoria, Australia.