Journal article

Gradient of Tissue Injury after Stroke: Rethinking the Infarct versus Noninfarcted Dichotomy

Felix Ng, Vijay Venkatraman, Mark Parsons, Andrew Bivard, Gagan Sharma, Leonid Churilov, Patricia Desmond, Stephen M Davis, Nawaf Yassi, Bruce Campbell



AIM: To evaluate the degree of variability in microstructural injury within and adjacent to regions identified as infarcted tissue using diffusion tensor imaging (DTI). METHODS: In this prospective longitudinal study, 18 patients presenting within 12 h of anterior circulation acute ischemic stroke who underwent CT perfusion (CTP) at baseline followed by fluid-attenuated inversion recovery (FLAIR) and DTI 1-month were analyzed. Four regions of interest (ROI) corresponding to the severity of hypoperfusion on CTP within and beyond the radiological infarct lesion defined on FLAIR were segmented. Fractional anisotropy (FA) and mean diffusivity (MD) were quantified for each ROI and compared to a m..

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