Journal article

Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition

Bernardo Rodriguez-Martin, Eva G Alvarez, Adrian Baez-Ortega, Jorge Zamora, Fran Supek, Jonas Demeulemeester, Martin Santamarina, Young Seok Ju, Javier Temes, Daniel Garcia-Souto, Harald Detering, Yilong Li, Jorge Rodriguez-Castro, Ana Dueso-Barroso, Alicia L Bruzos, Stefan C Dentro, Miguel G Blanco, Gianmarco Contino, Daniel Ardeljan, Marta Tojo Show all

Nature Genetics | NATURE PUBLISHING GROUP | Published : 2020

Grants

Awarded by European Research Council (ERC)


Awarded by Ramon y Cajal grant


Awarded by Spanish Ministry of Economy, Industry and Competitiveness (MINECO) grant


Awarded by Xunta de Galicia (Spain)


Awarded by ERC


Awarded by MINECO


Awarded by Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) - Ministry of Health & Welfare, Republic of Korea


Awarded by National Institutes of Health


Awarded by FEDER


Awarded by My First AIRC grant from the Associazione Italiana Ricerca sul Cancro


Awarded by European Union


Awarded by NIH


Awarded by American Heart Association Institutional Data Fellowship Award


Awarded by Cancer Research UK


Awarded by SNSF Early Postdoc Mobility fellowship


Awarded by EMBO Long-Term Fellowship


Awarded by Danish Medical Research Council


Awarded by Francis Crick Institute from Cancer Research UK


Awarded by UK Medical Research Council


Awarded by Wellcome Trust


Awarded by National Institute of General Medical Sciences


Awarded by TransTumVar project


Awarded by Wellcome Trust grant



Funding Acknowledgements

J.M.C.T. is supported by European Research Council (ERC) Starting Grant 716290 `SCUBA CANCERS', Ramon y Cajal grant RYC-2014-14999 and Spanish Ministry of Economy, Industry and Competitiveness (MINECO) grant SAF2015-66368-P. B.R.-M., E.G.A., M.S.G. and S.Z. are supported by PhD fellowships from Xunta de Galicia (Spain) ED481A-2016/151, ED481A-2017/299, ED481A-2017/306 and ED481A-2018/199, respectively. F.S. was supported by ERC Starting Grant 757700 `HYPER-INSIGHT', MINECO grant BFU2017-89833-P `RegioMut', and further acknowledges institutional funding from the MINECO Severo Ochoa award and from the CERCA Programme of the Catalan Government. Y.S.J. was supported by Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number HI16C2387).A.L.B. is supported by MINECO PhD fellowship BES-2016-078166. M.T. was supported by MINECO grant SAF2015-73916-JIN. R.B. received funding through the National Institutes of Health (U24CA210978 and R01CA188228). M.G.B. received funding through MINECO, AEI, Xunta de Galicia and FEDER (BFU2013-41554-P, BFU2016-78121-P, ED431F 2016/019). N.B. is supported by a My First AIRC grant from the Associazione Italiana Ricerca sul Cancro (number 17658). J.D. is a postdoctoral fellow of the Research Foundation Flanders (FWO) and the European Union's Horizon 2020 research and innovation program (Marie Sklodowska-Curie grant agreement number 703594-DECODE). K.C. and Z.C. are supported by NIH R01 CA172652 and U41 HG007497. Z.C. is supported by an American Heart Association Institutional Data Fellowship Award (17IF33890015). P.A.W.E. is supported by Cancer Research UK. E.A.L. is supported by K01AG051791. I.M. is supported by Cancer Research UK (C57387/A21777). F.M. is supported by A.I.L. (Associazione Italiana Contro le Leucemie-Linfomi e Mieloma ONLUS) and by S.I.E.S. (Societa Italiana di Ematologia Sperimentale). S.M.W. received funding through a SNSF Early Postdoc Mobility fellowship (P2ELP3_155365) and an EMBO Long-Term Fellowship (ALTF 755-2014). J.W. received funding from the Danish Medical Research Council (DFF-4183-00233). D.C.W. is funded by the Li Ka Shing foundation and the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre. J.O.K. is supported by an ERC Starting Grant. P.V.L. is a Winton Group Leader in recognition of the Winton Charitable Foundation's support towards the establishment of The Francis Crick Institute. This work is supported by The Francis Crick Institute, which receives its core funding from Cancer Research UK (FC001202), the UK Medical Research Council (FC001202) and the Wellcome Trust (FC001202). H.H.K. is supported by grants from the National Institute of General Medical Sciences (P50GM107632 and 1R01GM099875). K.H.B. is supported by P50GM107632, R01CA163705 and R01GM124531. This work was supported by the TransTumVar project PN013600. R.C.F. thanks Cancer Research UK Programme Grant for esophageal ICGC, Cambridge BRC and ECMC infrastructure support. This work was supported by the Wellcome Trust grant 09805. We acknowledge the contributions of the many clinical networks across the ICGC and TCGA who provided samples and data to the PCAWG Consortium, and the contributions of the Technical Working Group and the Germline Working Group of the PCAWG Consortium for collation, realignment and harmonized variant calling of the cancer genomes used in this study. We thank the patients and their families for their participation in the individual ICGC and TCGA projects.