Differential Response of the Chicken Trachea to Chronic Infection with Virulent Mycoplasma gallisepticum Strain Ap3AS and Vaxsafe MG (Strain ts-304): a Transcriptional Profile
Sathya N Kulappu Arachchige, Neil D Young, Pollob K Shil, Alistair R Legione, Anna Kanci Condello, Glenn F Browning, Nadeeka K Wawegama
INFECTION AND IMMUNITY | AMER SOC MICROBIOLOGY | Published : 2020
Mycoplasma gallisepticum is the primary etiological agent of chronic respiratory disease in chickens. Live attenuated vaccines are most commonly used in the field to control the disease, but current vaccines have some limitations. Vaxsafe MG (strain ts-304) is a new vaccine candidate that is efficacious at a lower dose than the current commercial vaccine strain ts-11, from which it is derived. In this study, the transcriptional profiles of the trachea of unvaccinated chickens and chickens vaccinated with strain ts-304 were compared 2 weeks after challenge with M. gallisepticum strain Ap3AS during the chronic stage of infection. After challenge, genes, gene ontologies, pathways, and protein c..View full abstract
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Awarded by Australian Research Council
This study was funded by Australian Research Council Linkage Project grant LP160101105. Sathya N. Kulappu Arachchige was supported by Melbourne International Fee Remission and Melbourne Research scholarships.