Journal article

External Validation of Risk Prediction Models Incorporating Common Genetic Variants for Incident Colorectal Cancer Using UK Biobank

Catherine L Saunders, Britt Kilian, Deborah J Thompson, Luke J McGeoch, Simon J Griffin, Antonis C Antoniou, Jon D Emery, Fiona M Walter, Joe Dennis, Xin Yang, Juliet A Usher-Smith

Cancer Prevention Research | AMER ASSOC CANCER RESEARCH | Published : 2020

Abstract

The aim of this study was to compare and externally validate risk scores developed to predict incident colorectal cancer that include common genetic variants (SNPs), with or without established lifestyle/environmental (questionnaire-based/classical/phenotypic) risk factors. We externally validated 23 risk models from a previous systematic review in 443,888 participants ages 37 to 73 from the UK Biobank cohort who had 6-year prospective follow-up, no prior history of colorectal cancer, and data for incidence of colorectal cancer through linkage to national cancer registries. There were 2,679 (0.6%) cases of incident colorectal cancer. We assessed model discrimination using the area under the ..

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Grants

Awarded by UK Biobank Resource


Awarded by Bowel Cancer UK


Awarded by Cancer Research UK Prevention Fellowship


Awarded by Cancer Research UK


Funding Acknowledgements

This research has been conducted using the UK Biobank Resource under Application Number 28126. This work was funded by a grant from Bowel Cancer UK (18PG0008). J.A. Usher-Smith is funded by a Cancer Research UK Prevention Fellowship (C55650/A21464). A.C. Antoniou and X. Yang are supported by a Cancer Research UK grant (C12292/A20861). DJT was supported by a Cancer Research UK grant (C1287/A16563). The University of Cambridge has received salary support in respect of S.J. Griffin from the NHS in the East of England through the Clinical Academic Reserve. The views expressed in this publication are those of the authors and not necessarily those of the National Health Service (NHS), the National Institute for Health Research (NIHR), or the Department of Health. All researchers were independent of the funding body, and the funder had no role in data collection, analysis, and interpretation of data; in the writing of the report; or decision to submit the article for publication.